Teshekpuk Lake is one of the most well-known places in the Reserve. The lake and its surrounding wetlands are ecologically unique and one of the most important wildlife habitats in the circumpolar Arctic. Known as an Important Birding Area of global significance, Teshekpuk Lake is home to large numbers of shore and water birds, such as the Pacific Black Brant and Greater White-fronted Goose. many of the birds that nest in Teshekpuk Lake during the summer migrate throughout the Lower 48 – it also is the largest goose molting area in the Arctic. Gray wolves, grizzly bears, polar bears, and the 67,000-strong Teshekpuk Lake Caribou Herd all thrive in this area. The North Slope communities depend upon the Teshekpuk Lake Caribou Herd as a vital food source for their subsistence culture.
- "We approached the lake by air across an undulating plain layered with meandering streams that formed chains of beaded lakes glimmering turquoise and aquamarine in the soft summer light."— Bruce Babbitt